Entrectinib
Product Specifications
CAS Number
1108743-60-7
Synonyms
RXDX-101, NMS-E628
Target
Trk receptor
Applications
Protein Tyrosine Kinase
Smiles
CN1CCN (CC1) C2=CC (=C (C=C2) C (=O) NC3=NNC4=C3C=C (C=C4) CC5=CC (=CC (=C5) F) F) NC6CCOCC6
Molecular Formula
C31H34F2N6O2
Additionnal Information
Entrectinib is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Entrectinib (RXDX-101) induces autophagy. Phase 2.
Storage Conditions
2 years -80 in solvent
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