PIM447 (LGH447) Hydrochloride
Product Specifications
CAS Number
1210416-52-6
Target
Pim
Applications
JAK/STAT
Smiles
CC1CC (CC (C1) N) C2=C (C=NC=C2) NC (=O) C3=NC (=C (C=C3) F) C4=C (C=CC=C4F) F
Molecular Formula
C24H23F3N4O.HCl
Additionnal Information
PIM447 (LGH447) Hydrochloride is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs) . PIM447 induces apoptosis.
Storage Conditions
2 years -80 in solvent
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb2805023 100 µg
Zebrafish Histone H3 Rabbit Polyclonal Antibody (Biotin)
Sign In for Pricing
View Details 
abx168943-01 10 µg
Human Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) Protein
Sign In for Pricing
View Details abx168943-02 50 µg
Human Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) Protein
Sign In for Pricing
View Details abx168943-03 100 µg
Human Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) Protein
Sign In for Pricing
View Details