What is the catalog number for PIM447 (LGH447) Hydrochloride?

The catalog number for PIM447 (LGH447) Hydrochloride is C13103-10mM/1mL.

What sizes are available for PIM447 (LGH447) Hydrochloride?

PIM447 (LGH447) Hydrochloride is available in the following size(s): 10 mM/1mL.

Is PIM447 (LGH447) Hydrochloride in stock?

PIM447 (LGH447) Hydrochloride is currently made to order / not held in immediate stock. Contact us for lead time.

Are there any special shipping requirements for PIM447 (LGH447) Hydrochloride?

PIM447 (LGH447) Hydrochloride is requires dry ice shipping.

PIM447 (LGH447) Hydrochloride

Product Specifications

CAS Number

1210416-52-6

Target

Pim

Applications

JAK/STAT

Smiles

CC1CC (CC (C1) N) C2=C (C=NC=C2) NC (=O) C3=NC (=C (C=C3) F) C4=C (C=CC=C4F) F

Molecular Formula

C24H23F3N4O.HCl

Additionnal Information

PIM447 (LGH447) Hydrochloride is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs) . PIM447 induces apoptosis.