Rottlerin
Product Specifications
CAS Number
82-08-6
Synonyms
Mallotoxin, NSC 56346, NSC 94525
Target
PKC
Applications
Cytoskeletal Signaling
Smiles
CC1=C (C (=C (C (=C1O) C (=O) C) O) CC2=C (C (=C3C (=C2O) C=CC (O3) (C) C) C (=O) C=CC4=CC=CC=C4) O) O
Molecular Formula
C30H28O8
Additionnal Information
Rottlerin (Mallotoxin, NSC 56346, NSC 94525), a natural compound purified from Mallotus Philippinensis, is a specific Protein kinase inhibitor with IC50 of 3 μM, 6 μM and 5.3 μM for PKCδ (from baculovirus-infected Sf9 insect cells), PKCδ (from porcine spleen) and CaM kinase III, respectively. Rottlerin also inhibits PKCα, PKCγ, PKCβ, PKCη, CKII and PKA with IC50 of 30 μM, 40 μM, 42 μM, 82 μM, 30 μM and 78 μM, respectively.
Storage Conditions
3 years -20°C powder
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