BI-847325
Product Specifications
CAS Number
1207293-36-4
Target
MEK
Applications
Protein Tyrosine Kinase
Smiles
CCNC (=O) C#CC1=CC2=C (C=C1) C (=C (N2) O) C (=NC3=CC=C (C=C3) CN (C) C) C4=CC=CC=C4
Molecular Formula
C29H28N4O2
Additionnal Information
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
Storage Conditions
2 years -80 in solvent
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