Dorsomorphin
Product Specifications
CAS Number
866405-64-3
Synonyms
BML-275, Compound C
Target
AMPK
Applications
PI3K/Akt/mTOR
Smiles
C1CCN (CC1) CCOC2=CC=C (C=C2) C3=CN4C (=C (C=N4) C5=CC=NC=C5) N=C3
Molecular Formula
C24H25N5O
Additionnal Information
Dorsomorphin is a potent, reversible, selective AMPK inhibitor with Ki of 109 nM in cell-free assays, exhibiting no significant inhibition of several structurally related kinases including ZAPK, SYK, PKCθ, PKA, and JAK3. Dorsomorphin selectively inhibits the BMP type I receptors ALK2, ALK3 and ALK6. Dorsomorphin is used in promoting specific cell differentiation and inducing cancer cell line autophagy. For cell testing, the water-soluble S7306 Dorsomorphin (Compound C) 2HCl is recommended.
Storage Conditions
2 years -80 in solvent
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