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Nazartinib (EGF816)

Product Specifications

CAS Number

1508250-71-2

Synonyms

NVS-816

Target

EGFR

Applications

Protein Tyrosine Kinase

Smiles

CC1=NC=CC (=C1) C (=O) NC2=NC3=C (N2C4CCCCN (C4) C (=O) C=CCN (C) C) C (=CC=C3) Cl

Molecular Formula

C26H31ClN6O2

Additionnal Information

Nazartinib (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (L858R, ex19del) and T790M mt, with up to 60-fold selectivity over wild type (wt) EGFR in vitro.

Storage Conditions

2 years -80 in solvent

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