MI-503
Product Specifications
CAS Number
1857417-13-0
Target
Histone Methyltransferase
Applications
Epigenetics
Smiles
CC1=C (C=CC2=C1C=C (N2CC3=CNN=C3) C#N) CN4CCC (CC4) NC5=C6C=C (SC6=NC=N5) CC (F) (F) F
Molecular Formula
C28H27F3N8S
Additionnal Information
MI-503 is a potent and selective Menin-MLL inhibitor with IC50 of 14.7 nM. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines (GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations.
Storage Conditions
2 years -80 in solvent
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