Afatinib Dimaleate

Product Specifications

CAS Number

850140-73-7

Synonyms

BIBW2992 Dimaleate

Target

EGFR

Applications

Protein Tyrosine Kinase

Smiles

CN (C) CC=CC (=O) NC1=C (C=C2C (=C1) C (=NC=N2) NC3=CC (=C (C=C3) F) Cl) OC4CCOC4.C (=CC (=O) O) C (=O) O.C (=CC (=O) O) C (=O) O

Molecular Formula

C24H25ClFN5O3.2C4H4O4

Additionnal Information

Afatinib Dimaleate irreversibly inhibits EGFR/HER2 including EGFR (wt), EGFR (L858R), EGFR (L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Afatinib (BIBW2992) Dimaleate induces autophagy.