Purvalanol A
Product Specifications
CAS Number
212844-53-6
Target
CDK
Applications
Cell Cycle
Smiles
CC (C) C (CO) NC1=NC (=C2C (=N1) N (C=N2) C (C) C) NC3=CC (=CC=C3) Cl
Molecular Formula
C19H25ClN6O
Additionnal Information
Purvalanol A is a potent, and cell-permeable CDK inhibitor with IC50 of 4 nM, 70 nM, 35 nM, and 850 nM for cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, and cdk4-cyclin D1, respectively. Purvalanol A induces endoplasmic reticulum stress-mediated apoptosis and autophagy.
Storage Conditions
2 years -80 in solvent
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