Sunitinib
Product Specifications
CAS Number
557795-19-4
Synonyms
SU11248
Target
PDGFR
Applications
Protein Tyrosine Kinase
Smiles
CCN (CC) CCNC (=O) C1=C (NC (=C1C) C=C2C3=C (C=CC (=C3) F) NC2=O) C
Molecular Formula
C22H27FN4O2
Additionnal Information
Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. Sunitinib is also a dose-dependent inhibitor of the autophosphorylation activity of IRE1α. Sunitinib induces autophagy and apoptosis.
Storage Conditions
2 years -80 in solvent
Frequently Asked Questions
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