VER155008
Product Specifications
CAS Number
1134156-31-2
Target
HSP (HSP90)
Applications
Cytoskeletal Signaling
Smiles
C1=CC (=CC=C1COCC2C (C (C (O2) N3C4=NC=NC (=C4N=C3NCC5=CC (=C (C=C5) Cl) Cl) N) O) O) C#N
Molecular Formula
C25H23Cl2N7O4
Additionnal Information
VER155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78 (HSPA5, Bip), respectively, >100-fold selectivity over HSP90. VER155008 inhibits autophagy and causes reduced levels of HSP90 client proteins.
Storage Conditions
2 years -80 in solvent
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