A-83-01
Product Specifications
CAS Number
909910-43-6
Target
TGF-beta/Smad
Applications
TGF-beta/Smad
Smiles
CC1=NC (=CC=C1) C2=NN (C=C2C3=CC=NC4=CC=CC=C34) C (=S) NC5=CC=CC=C5
Molecular Formula
C25H19N5S
Additionnal Information
A-83-01 is a potent inhibitor of TGF-β type I receptor (ALK5-TD) with IC50 of 12 nM. A-83-01 also inhibits the transcription induced by activin/nodal type I receptor (ALK4-TD) and nodal type I receptor (ALK7-TD) with IC50 of 45 nM and 7.5 nM, respectively.Solutions are unstable and should be fresh-prepared.
Storage Conditions
2 years -80 in solvent
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