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Ki20227

Product Specifications

CAS Number

623142-96-1

Target

CSF-1R

Applications

Protein Tyrosine Kinase

Smiles

CC (C1=NC=CS1) NC (=O) NC2=C (C=C (C=C2) OC3=C4C=C (C (=CC4=NC=C3) OC) OC) OC

Molecular Formula

C24H24N4O5S

Additionnal Information

Ki20227 is an orally active and highly selective inhibitor of c-Fms tyrosine kinase (CSF1R) with IC50 of 2 nM, 12 nM, 451 nM and 217 nM for c-Fms, vascular endothelial growth factor receptor-2 (KDR/VEGFR-2), stem cell factor receptor (c-Kit), and platelet-derived growth factor receptor beta (PDGFRβ), respectively.

Storage Conditions

3 years -20°C powder

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