ML141
Product Specifications
CAS Number
71203-35-5
Synonyms
CID-2950007
Target
Rho
Applications
Cell Cycle
Smiles
COC1=CC=C (C=C1) C2CC (=NN2C3=CC=C (C=C3) S (=O) (=O) N) C4=CC=CC=C4
Molecular Formula
C22H21N3O3S
Additionnal Information
ML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7) . ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 also protects neuroblastoma cells from metformin-induced apoptosis.
Storage Conditions
2 years -80 in solvent
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