Aphidicolin
Product Specifications
CAS Number
38966-21-1
Target
DNA/RNA Synthesis
Applications
Cell Cycle
Smiles
C[C@@]12[C@]34[C@] (CC[C@@]1 ([H]) [C@@] (C) ([C@H] (O) CC2) CO) ([H]) C[C@] ([C@] (CO) (O) CC4) ([H]) C3
Molecular Formula
C20H34O4
Additionnal Information
Aphidicolin is a tetracyclic diterpenoid antibiotic produced by *Cephalosporium aphidicola* that specifically inhibits eukaryotic DNA polymerases α and δ, thereby blocking DNA replication and mitotic cell division. This compound demonstrates broad antiviral activity, including inhibition of herpes simplex virus replication and anti-orthopoxvirus effects. Additionally, aphidicolin enhances arabinosyl nucleoside-induced apoptosis in HL-60 human promyelocytic leukemia cells.
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