OTS964
Product Specifications
CAS Number
1338545-07-5
Target
TOPK
Applications
MAPK
Smiles
CC1=CC (=C (C2=C1NC (=O) C3=C2C=CS3) C4=CC=C (C=C4) C (C) CN (C) C) O.Cl
Molecular Formula
C23H24N2O2S.HCl
Additionnal Information
OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. OTS964 treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.
Storage Conditions
2 years -80 in solvent
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