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3PO

Product Specifications

CAS Number

18550-98-6

Synonyms

3- (3-pyridinyl) -1- (4-pyridinyl) -2-propen-1-one

Target

PFKFB

Applications

Apoptosis

Smiles

C1=CC (=CN=C1) C=CC (=O) C2=CC=NC=C2

Molecular Formula

C13H10N2O

Additionnal Information

3PO (3- (3-pyridinyl) -1- (4-pyridinyl) -2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.

Storage Conditions

2 years -80 in solvent

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