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TH588

Product Specifications

CAS Number

1609960-31-7

Target

MTH1

Applications

DNA Damage/DNA Repair

Smiles

C1CC1NC2=NC (=NC (=C2) C3=C (C (=CC=C3) Cl) Cl) N

Molecular Formula

C13H12Cl2N4

Additionnal Information

TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.

Storage Conditions

2 years -80 in solvent

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