GSK J1
Product Specifications
CAS Number
1373422-53-7
Target
Histone Demethylase
Applications
Epigenetics
Smiles
C1CN (CCC2=CC=CC=C21) C3=NC (=NC (=C3) NCCC (=O) O) C4=CC=CC=N4
Molecular Formula
C22H23N5O2
Additionnal Information
GSK-J1 is a highly potent inhibitor of H3K27 histone demethylase JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 60 nM in cell-free assays for JMJD3 (KDM6B), respectively, >10-fold selectivity over other tested demethylases, with IC50 of 0.95μM and 1.76μM towards JARID1B/C.
Storage Conditions
2 years -80 in solvent
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