What is the catalog number for Leptomycin B?

The catalog number for Leptomycin B is C12793-10mM/1mL.

What sizes are available for Leptomycin B?

Leptomycin B is available in the following size(s): 10 mM/1mL.

Is Leptomycin B in stock?

Leptomycin B is currently made to order / not held in immediate stock. Contact us for lead time.

Leptomycin B

Product Specifications

CAS Number

87081-35-4

Synonyms

LMB, CI 940, Elactocin, Mantuamycin, NSC 364372

Target

CRM1

Applications

Transmembrane Transporters

Smiles

CCC (/C=C/C1OC (=O) C=CC1C) =C/C (C) C/C=C/C (C) =C/C (C) C (=O) C (C) C (O) C (C) C\C (C) =C\C (O) =O

Molecular Formula

C33H48O6

Additionnal Information

Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM–10 nM.