Leptomycin B
Product Specifications
CAS Number
87081-35-4
Synonyms
LMB, CI 940, Elactocin, Mantuamycin, NSC 364372
Target
CRM1
Applications
Transmembrane Transporters
Smiles
CCC (/C=C/C1OC (=O) C=CC1C) =C/C (C) C/C=C/C (C) =C/C (C) C (=O) C (C) C (O) C (C) C\C (C) =C\C (O) =O
Molecular Formula
C33H48O6
Additionnal Information
Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM–10 nM.
Storage Conditions
3 years -20°C powder
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