WH-4-023
Product Specifications
CAS Number
837422-57-8
Synonyms
KIN001-112, KIN112, Dual LCK/SRC inhibitor
Target
Src
Applications
Protein Tyrosine Kinase
Smiles
CC1=C (C (=CC=C1) C) OC (=O) N (C2=C (C=C (C=C2) OC) OC) C3=NC (=NC=C3) NC4=CC=C (C=C4) N5CCN (CC5) C
Molecular Formula
C32H36N6O4
Additionnal Information
WH-4-023 (KIN001-112, KIN112, Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.
Storage Conditions
2 years -80 in solvent
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