Lorlatinib (PF-6463922)
Product Specifications
CAS Number
1454846-35-5
Target
ALK
Applications
Protein Tyrosine Kinase
Smiles
CC1C2=C (C=CC (=C2) F) C (=O) N (CC3=NN (C (=C3C4=CC (=C (N=C4) N) O1) C#N) C) C
Molecular Formula
C21H19FN6O2
Additionnal Information
Lorlatinib (PF-6463922) is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively. PF-06463922 induces apoptosis. Phase 1.
Storage Conditions
2 years -80 in solvent
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