Entospletinib (GS-9973)
Product Specifications
CAS Number
1229208-44-9
Target
Syk
Applications
Protein Tyrosine Kinase
Smiles
C1COCCN1C2=CC=C (C=C2) NC3=NC (=CN4C3=NC=C4) C5=CC6=C (C=C5) C=NN6
Molecular Formula
C23H21N7O
Additionnal Information
Entospletinib (GS-9973) is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM in a cell-free assay and showed 13- to >1000-fold cellular selectivity for Syk over other kinases (including Jak2, ckit, Flt3, Ret, KDR) as assessed by target protein phosphorylation or functional response.
Storage Conditions
2 years -80 in solvent
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