AZD7545
Product Specifications
CAS Number
252017-04-2
Target
PDHK
Applications
Metabolism
Smiles
CC (C (=O) NC1=C (C=C (C=C1) S (=O) (=O) C2=CC=C (C=C2) C (=O) N (C) C) Cl) (C (F) (F) F) O
Molecular Formula
C19H18ClF3N2O5S
Additionnal Information
AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. It failed to inhibit PDHK4 at higher concentrations (>10 nM), AZD7545 stimulates PDHK4 activity.
Storage Conditions
2 years -80 in solvent
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