Poziotinib
Product Specifications
CAS Number
1092364-38-9
Synonyms
HM781-36B, NOV120101
Target
HER2
Applications
Protein Tyrosine Kinase
Smiles
COC1=C (C=C2C (=C1) N=CN=C2NC3=C (C (=C (C=C3) Cl) Cl) F) OC4CCN (CC4) C (=O) C=C
Molecular Formula
C23H21Cl2FN4O3
Additionnal Information
Poziotinib is an irreversible pan-HER inhibitor with IC50 of 3.2 nM, 5.3 nM and 23.5 nM for HER1, HER2, and HER4, respectively. Poziotinib also induces apoptosis and G1 cell cycle arrest. Phase 2.
Storage Conditions
2 years -80 in solvent
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