GSK2606414
Product Specifications
CAS Number
1337531-36-8
Target
PERK
Applications
Apoptosis
Smiles
CN1C=C (C2=C (N=CN=C21) N) C3=CC4=C (C=C3) N (CC4) C (=O) CC5=CC (=CC=C5) C (F) (F) F
Molecular Formula
C24H20F3N5O
Additionnal Information
GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. GSK2606414 impairs GANT-61 induced autophagy in NB cells with MYCN amplification. GSK2606414 exacerbates ER stress-induced apoptosis in HCT116 cells while reduces the apoptosis in SIL1 KD HeLa cells.
Storage Conditions
2 years -80 in solvent
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