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Onvansertib (NMS-P937)

Product Specifications

CAS Number

1034616-18-6

Synonyms

PCM-075, NMS1286937

Target

PLK

Applications

Cell Cycle

Smiles

CN1CCN (CC1) C2=CC (=C (C=C2) OC (F) (F) F) NC3=NC=C4CCC5=C (C4=N3) N (N=C5C (=O) N) CCO

Molecular Formula

C24H27F3N8O3

Additionnal Information

Onvansertib (NMS-P937, PCM-075, NMS1286937) is an orally available, selective Polo-like Kinase 1 (PLK1) inhibitor with IC50 of 2 nM, 5000-fold selectivity over PLK2/PLK3. Onvansertib (NMS-P937) potently causes a mitotic cell-cycle arrest followed by apoptosis in cancer cell lines and inhibits tumor growth. Phase 1.

Storage Conditions

2 years -80 in solvent

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