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Bisindolylmaleimide I (GF109203X)

Product Specifications

CAS Number

133052-90-1

Synonyms

GO 6850

Target

PKC

Applications

Cytoskeletal Signaling

Smiles

CN (C) CCCN1C=C (C2=CC=CC=C21) C3=C (C (=O) NC3=O) C4=CNC5=CC=CC=C54

Molecular Formula

C25H24N4O2

Additionnal Information

Bisindolylmaleimide I (GF109203X, GO 6850) is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.

Storage Conditions

2 years -80 in solvent

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