Fosbretabulin (Combretastatin A4 Phosphate) Disodium
Product Specifications
CAS Number
168555-66-6
Synonyms
CA 4DP
Target
Microtubule Associated
Applications
Cytoskeletal Signaling
Smiles
COC1=C (C=C (C=C1) C=CC2=CC (=C (C (=C2) OC) OC) OC) OP (=O) ([O-]) [O-].[Na+].[Na+]
Molecular Formula
C18H19O8P.2Na
Additionnal Information
Fosbretabulin (Combretastatin A4 Phosphate) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3.
Storage Conditions
2 years -80 in solvent
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC740178-500 1x 500 µL
CD50 (ICAM-3) (186-2G9), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740040-500 1x 500 µL
CD35 / CR1 (E11), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680676-500 1x 500 µL
MUC18 / Mucin 18 / CD146 (OJ79c), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC741203-100 1x 100 µL
Smooth Muscle Actin (ACTA2/791 +1A4), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details