BIO
Product Specifications
CAS Number
667463-62-9
Synonyms
GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052
Target
GSK-3
Applications
PI3K/Akt/mTOR
Smiles
C1=CC=C2C (=C1) C (=C (N2) C3=C (NC4=C3C=CC (=C4) Br) O) N=O
Molecular Formula
C16H10BrN3O2
Additionnal Information
BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor with IC50 of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells.
Storage Conditions
2 years -80 in solvent
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