PF-543 hydrochloride
Product Specifications
CAS Number
1706522-79-3
Target
SPHK
Applications
Immunology & Inflammation
Smiles
CC1=CC (=CC (=C1) OCC2=CC=C (C=C2) CN3CCCC3CO) CS (=O) (=O) C4=CC=CC=C4.Cl
Molecular Formula
C27H32ClNO4S
Additionnal Information
PF-543 hydrochloride, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM, exhibits >100-fold selectivity over the SphK2 isoform. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy.
Storage Conditions
2 years -80 in solvent
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