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Spebrutinib (AVL-292)

Product Specifications

CAS Number

1202757-89-8

Synonyms

CC-292

Target

BTK

Applications

Protein Tyrosine Kinase

Smiles

COCCOC1=CC=C (C=C1) NC2=NC=C (C (=N2) NC3=CC (=CC=C3) NC (=O) C=C) F

Molecular Formula

C22H22FN5O3

Additionnal Information

Spebrutinib (AVL-292) is a covalent, orally active, and highly selective BTK inhibitor with IC50 of <0.5 nM, displaying at least 1400-fold selectivity over the other kinases assayed. Phase 1.

Storage Conditions

2 years -80 in solvent

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