Setanaxib (GKT137831)
Product Specifications
CAS Number
1218942-37-0
Synonyms
GKT831
Target
NADPH-oxidase
Applications
Immunology & Inflammation
Smiles
CN1C (=O) C=C2C (=C1C3=CC (=CC=C3) N (C) C) C (=O) N (N2) C4=CC=CC=C4Cl
Molecular Formula
C21H19ClN4O2
Additionnal Information
Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. GKT137831 partly inhibits ferroptosis.
Storage Conditions
2 years -80 in solvent
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