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Setanaxib (GKT137831)

Product Specifications

CAS Number

1218942-37-0

Synonyms

GKT831

Target

NADPH-oxidase

Applications

Immunology & Inflammation

Smiles

CN1C (=O) C=C2C (=C1C3=CC (=CC=C3) N (C) C) C (=O) N (N2) C4=CC=CC=C4Cl

Molecular Formula

C21H19ClN4O2

Additionnal Information

Setanaxib (GKT137831, GKT831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. GKT137831 partly inhibits ferroptosis.

Storage Conditions

2 years -80 in solvent

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