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Tazemetostat (EPZ-6438)

Product Specifications

CAS Number

1403254-99-8

Synonyms

E7438

Target

Histone Methyltransferase

Applications

Epigenetics

Smiles

CCN (C1CCOCC1) C2=CC (=CC (=C2C) C (=O) NCC3=C (C=C (NC3=O) C) C) C4=CC=C (C=C4) CN5CCOCC5

Molecular Formula

C34H44N4O4

Additionnal Information

Tazemetostat (EPZ-6438, E7438) is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs.

Storage Conditions

2 years -80 in solvent

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