Marinopyrrole A (Maritoclax)
Product Specifications
CAS Number
1227962-62-0
Target
Bcl-2
Applications
Apoptosis
Smiles
C1=CC=C (C (=C1) C (=O) C2=CC (=C (N2C3=C (NC (=C3Cl) Cl) C (=O) C4=CC=CC=C4O) Cl) Cl) O
Molecular Formula
C22H12Cl4N2O4
Additionnal Information
Marinopyrrole A (Maritoclax) is a selective Mcl-1 antagonist. It binds to Mcl-1, but not Bcl-XL, and targets Mcl-1 for proteasomal degradation. Maritoclax disrupts the interaction between Bim and Mcl-1 with an IC50 of 10.1 μM.
Storage Conditions
2 years -80 in solvent
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