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Brefeldin A (BFA)

Product Specifications

CAS Number

20350-15-6

Synonyms

Cyanein, Decumbin

Target

ATPase

Applications

Transmembrane Transporters

Smiles

CC1CCCC=CC2CC (CC2C (C=CC (=O) O1) O) O

Molecular Formula

C16H24O4

Additionnal Information

Brefeldin A (BFA) is a lactone antibiotic and ATPase inhibitor for protein transport with IC50 of 0.2 μM in HCT 116 cells, induces cancer cell differentiation and apoptosis. It could also improve the HDR (homology-directed repair) efficiency and be an enhancer of CRISPR-mediated HDR. Brefeldin A is also an inhibitor of autophagy and mitophagy.

Storage Conditions

2 years -80 in solvent

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