Merestinib (LY2801653)
Product Specifications
CAS Number
1206799-15-6
Target
C-Met
Applications
Protein Tyrosine Kinase
Smiles
CC1=CC=C (C (=O) N1C2=CC=C (C=C2) F) C (=O) NC3=CC (=C (C=C3) OC4=C (C=C5C (=C4) C=NN5C) C6=CNN=C6) F
Molecular Formula
C30H22F2N6O3
Additionnal Information
Merestinib (LY2801653) is a type-II ATP competitive, slow-off inhibitor of Met (c-Met) tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min (-1) and t1/2 of 525 min. Merestinib (LY2801653) also inhibits MST1R, AXL, ROS1, MKNK1/2, FLT3, MERTK, DDR1 and DDR2 with IC50 of 11 nM, 2 nM, 23 nM, 7 nM, 7 nM, 10 nM, 0.1 nM and 7 nM, respectively.
Storage Conditions
2 years -80 in solvent
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