GDC-0152
Product Specifications
CAS Number
873652-48-3
Target
IAP
Applications
Apoptosis
Smiles
CC (C (=O) NC (C1CCCCC1) C (=O) N2CCCC2C (=O) NC3=C (N=NS3) C4=CC=CC=C4) NC
Molecular Formula
C25H34N6O3S
Additionnal Information
GDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM in cell-free assays, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1.
Storage Conditions
2 years -80 in solvent
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