LC-2
Product Specifications
CAS Number
2502156-03-6
Synonyms
PROTAC KRASG12C Degrader-LC-2
Target
Ras
Applications
Apoptosis
Molecular Formula
C59H71ClFN11O7S
Additionnal Information
LC-2 is a first PROTAC capable of degrading endogenous KRASG12C with DC50s between 0.25 μM and 0.76 μM. LC-2 covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling.
Storage Conditions
3 years -20°C powder
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