What is the catalog number for AMG-9810?

The catalog number for AMG-9810 is C12328-5mg.

What sizes are available for AMG-9810?

AMG-9810 is available in the following size(s): 5 mg.

Is AMG-9810 in stock?

AMG-9810 is currently made to order / not held in immediate stock. Contact us for lead time.

AMG-9810

Product Specifications

CAS Number

545395-94-6

Target

TRP Channel

Applications

Neuronal Signaling

Smiles

CC (C) (C) C1=CC=C (/C=C/C (=O) NC2=CC=C3OCCOC3=C2) C=C1

Molecular Formula

C21H23NO3

Additionnal Information

AMG-9810 is a potent, competitive and selective vanilloid receptor 1 (TRPV1) antagonist and inhibits capsaicin activation with IC50 of 24.5 nM and 85.6 nM for human TRPV1 and rat TRPV1, repectively. AMG-9810 blocks all known modes of TRPV1 activation, including protons-, heat-, and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. AMG-9810 significantly reduces the mRNA expression of TLR2 and TLR4. AMG-9810 also promotes mouse skin tumorigenesis mediated through EGFR/Akt/mTOR signaling.