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PIN1 inhibitor API-1

Product Specifications

CAS Number

680622-70-2

Target

DNA/RNA Synthesis

Applications

Cell Cycle

Smiles

NC1=NC2=NC=NC2=C ([NH]1) OCC3=CC=C (CNC (=O) C (F) (F) F) C=C3

Molecular Formula

C15H13F3N6O2

Additionnal Information

PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor with IC50 of 72.3 nM. PIN1 inhibitor API-1 targets Pin1 peptidyl-prolyl isomerase domain and inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 up-regulates miRNA biogenesis by retaining active XPO5 conformation and suppresses HCC development.

Storage Conditions

3 years -20°C powder

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