Gossypol

Product Specifications

CAS Number

303-45-7

Synonyms

BL 193

Target

Dehydrogenase

Applications

Metabolism

Smiles

CC1=CC2=C (C (=C (C (=C2C (C) C) O) O) C=O) C (=C1C3=C (C4=C (C=C3C) C (=C (C (=C4C=O) O) O) C (C) C) O) O

Molecular Formula

C30H30O8

Additionnal Information

Gossypol (BL 193) is an orally-active polyphenol isolated from cotton seeds and roots. Gossypol is a potent inhibitor of 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase with IC50 of 3.33 μM and 0.52 μM in cell-free assay, respectively. Gossypol also inhibits the binding of BH3 peptide to Bcl protein with IC50 of 0.4 μM and 10 μM for Bcl-XL and Bcl-2, respectively. Gossypol induces apoptosis and cell growth inhibition in various cancer cells.