Gossypol
Product Specifications
CAS Number
303-45-7
Synonyms
BL 193
Target
Dehydrogenase
Applications
Metabolism
Smiles
CC1=CC2=C (C (=C (C (=C2C (C) C) O) O) C=O) C (=C1C3=C (C4=C (C=C3C) C (=C (C (=C4C=O) O) O) C (C) C) O) O
Molecular Formula
C30H30O8
Additionnal Information
Gossypol (BL 193) is an orally-active polyphenol isolated from cotton seeds and roots. Gossypol is a potent inhibitor of 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase with IC50 of 3.33 μM and 0.52 μM in cell-free assay, respectively. Gossypol also inhibits the binding of BH3 peptide to Bcl protein with IC50 of 0.4 μM and 10 μM for Bcl-XL and Bcl-2, respectively. Gossypol induces apoptosis and cell growth inhibition in various cancer cells.
Storage Conditions
3 years -20°C powder
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