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GRL0617

Product Specifications

CAS Number

1093070-16-6

Target

DUB

Applications

Ubiquitin

Smiles

CC1=C (C=C (C=C1) N) C (=O) NCCC2=CC=CC3=CC=CC=C32

Molecular Formula

C20H20N2O

Additionnal Information

GRL0617 is a potent, selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLPro) /deubiquitinase with IC50 of 0.6 μM and Ki of 0.49 μM. GRL0617 inhibits SARS-CoV viral replication in Vero E6 cells with EC50 of 15 microM and has no associated cytotoxicity.

Storage Conditions

3 years -20°C powder

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