O-Phenanthroline
Product Specifications
CAS Number
66-71-7
Synonyms
1,10-Phenanthroline, phen
Target
MMP
Applications
Proteases
Smiles
C1=CC2=C (C3=C (C=CC=N3) C=C2) N=C1
Molecular Formula
C12H8N2
Additionnal Information
O-Phenanthroline (1,10-Phenanthroline, phen), a hypoxia-mimicking agent, is a non-specific matrix metalloproteinase (MMP) inhibitor with IC50 of 110.5μM for Collagenase. O-phenanthroline reduces the expression of MMP3 and MMP13 mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFα/IL-1β exposure in an explant model. o-Phenanthroline is also a metal chelator which prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2+ that absorbs maximally at 510 nm.
Storage Conditions
3 years -20°C powder
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