JG98
Product Specifications
CAS Number
1456551-16-8
Target
HSP (HSP90)
Applications
Cytoskeletal Signaling
Smiles
CCN1C (=CC2=[N+] (C=CS2) CC3=CC=CC=C3) SC (=C4N (C5=C (S4) C=C (C=C5) Cl) C) C1=O.[Cl-]
Molecular Formula
C24H21Cl2N3OS3
Additionnal Information
JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. JG-98 induces classical apoptosis features, including morphological changes consistent with programmed cell death and positive annexin staining. JG-98 exhibits anticancer activity.
Storage Conditions
3 years -20°C powder
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