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TQB3804

Product Specifications

CAS Number

2267329-76-8

Synonyms

EGFR-IN-7

Target

EGFR

Applications

Protein Tyrosine Kinase

Smiles

CC1=CC (=C (C=C1N2CCC (CC2) N3CCN (CC3) C) OC) NC4=NC=C (C (=N4) NC5=C (C6=NC=CN=C6C=C5) P (=O) (C) C) Br

Molecular Formula

C32H41BrN9O2P

Additionnal Information

TQB3804 is a selective and potent EGFR kinase inhibitor with IC50 of 0.46 nM, 0.13 nM, 0.26 nM, 0.19 nM and 1.07 nM for for EGFRd746-750/T790M/C797S, EGFRL858R/T790M/C797S, EGFRd746-750/T790M, EGFRL858R/T790M and EGFRWT, respectively. TQB3804 (EGFR-IN-7) shows anti-tumor activity.

Storage Conditions

3 years -20°C powder

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